永田 祥平

We have long accepted that new biological information is mostly derived from random‚ error-based’ events. But abundant empirical evidence establishes the crucial role of non-random genetic content operators (non-coding regulatory DNA) acting through the expression of RNA with its complex biology to create complex regulatory control. Along with the parallel comeback of regulatory RNA in virology, RNA is now at center stage in how we think about complex organisms. Regulatory RNAs derive from infectious events and can co-operate, build communities, generate nucleotide sequences de novo and insert/delete them into host genetic content. In this sense RNAs determine host genetic identities throughout all kingdoms including the virosphere. But inclusion of a transmissive viral biology differs fundamentally from conventional thinking in that it represent a vertical domain of life providing vast amounts of linked information not derrived from direct ancestors. Interestingly single RNA stem loops react as a physico-chemical entities, whereas with the cooperation of various RNA stem-loops, networks and biological selection emerges. Thus we can argue, that for DNA based organisms, an abundance of infective clouds of RNA groups are a central driving force of evolution which are co-adapted from persistent infectious agents that serve as regulatory tools in nearly all cellular processes. Additionally, the resulting productive RNA-networks constantly produce new sequence space, wh...